Edward H. Wetherell died on September 25, 1857, at the age of 35. He was buried in Block 9 of Sandusky's Oakland Cemetery. The interment card from Oakland Cemetery indicates that Edward H. Wetherell died of consumption.
Several lodge symbols are found on Mr. Wetherell's tombstone. including the Masonic eye, the masonic square, and the Odd Fellows symbol containing three intertwining circles, which represent friendship, love, and truth.
The 1855 Sandusky City Directory lists another member of the Wetherell family, Mr. W. W. Wetherell, who owned the Fulton Car Works, which manufactured railroad cars.